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Nonmedical use and abuse of prescription opioids is an increasing public health problem. Intravenous (IV) administration of opioid analgesics intended for oral use is not uncommon; yet, little is known about the relative abuse potential of these drugs when administered intravenously to recreational opioid abusers without physical dependence.

Intravenous oxycodone, hydrocodone, and morphine in recreational opioid users: abuse potential and relative potencies