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We examined whether escalating doses of potassium bicarbonate (KHCO 3 ) supplements alter urinary nitrogen excretion expressed as a ratio to same day nitrogen intake (measure of muscle-protein breakdown). The ratio declined significantly from placebo to low to high dose of KHCO 3 supplementation in older adults over 3 months, suggesting muscle-sparing.

Increasing alkali supplementation decreases urinary nitrogen excretion when adjusted for same day nitrogen intake