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One century after the seminal work by Leonor Michaelis and Maud Menten devoted to the theoretical study of the enzymatic reactions, in this paper, we give an overview of the most recent trends concerning the mathematical modeling of several enzymatic mechanisms, focusing on its asymptotic analysis, which needs the use of advanced mathematical tools, such as center manifold theory, normal forms, and bifurcation theory. Moreover, we present some perspectives, linking the models here presented with similar models, arising from different research fields

New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis–Menten paper