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Dear Editor  Pediatric delirium (PD) has an estimated incidence of 4–16.9%. Three motoric subtypes are distinguished: hyperactive, hypoactive, and mixed. Current screening scales used are the Delirium Rating Scale (DRS) [1], the Pediatric Anesthesia Emergence Delirium Scale (PAED) [2], and the pCAM-ICU [3]. These scales are not well suited for the PICU setting, however, either because they have not been validated for this setting or are age inappropriate.  Our group validated the Sophia Observation withdrawal Symptoms scale to assess withdrawal symptoms in critically ill children [4]. As withdrawal syndrome is a possible cause of delirium, we assumed that symptoms of both conditions may overlap.  To confirm this, we retrieved medical and nursing records of 29 patients (12 girls) admitted to two PICUs in The Netherlands from January 2001 to March 2009 with a child and adolescent psychiatrist-confirmed diagnosis of delirium. Table 1 gives the demographic characteristics. Two researchers (MvD, EI) independently documented all symptoms suspected to indicate delirium recorded in the period from 48 h before to 48 h after the psychiatrist’s consultation. Discrepancies were discussed until consensus was reached. The result was 19 different symptoms, 10 of which are included in the SOS (Table 2). Five of the 19 symptoms correspond with the major delirium symptoms in the DSM-IV [5]. Almost all patients showed agitation, defined as irritability; attempts to pull out lines, tubes, or catheters; restlessness or fidgeting. Twenty-two patients (76%) showed hallucinations, mostly visual hallucinations.    Table 1  Characteristics of 29 patients with delirium      Table 2  Symptoms of delirium reported by nurses and psychiatrists (N = 29 patients)    Only a few symptoms suggested hypoactive delirium, such as decreased consciousness, impaired memory, and attentional deficits. We propose that adding these symptoms to the SOS, as well as lethargy and decreased motor activity, would make the SOS sensitive for hypoactive delirium as well. However, if hypoactive delirium is suspected from the observed symptoms, a child and adolescent psychiatrist should make a differential diagnosis to exclude a depressive disorder or adjustment disorder with anxiety or depression. Furthermore, hypoactive delirium in children must be differentiated from regressive behavior, stress, or a dissociative/conversion disorder.  We think the way to validate the extended SOS scale is to suspect delirium if at least one of the items from category B (far right column, Table 2) is observed. The acute onset and fluctuations of symptoms (e.g., sleepy during the daytime and delirious during the night) typical for delirium require repeated assessments 24 h per day.  Limitations of this study are its retrospective nature and the small sample size. Furthermore, preverbal children were underrepresented, perhaps because hallucinations and hypoactive delirium are difficult to diagnose in the very young [6, 7]. This could mean that the real incidence of delirium in these patients may be much higher than now observed in daily practice. Future studies, therefore, should focus on detecting delirium in preverbal children. One way to go is to ask parents of young children with suspected delirium how the child’s behavior compares to the usual behavior. Future studies should also find better ways to identify hypoactive delirium and its risk factors. Next, RCTs could identify the most effective pharmacological treatment for delirium in children.

Screening pediatric delirium with an adapted version of the Sophia Observation withdrawal Symptoms scale (SOS)