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The cumulative effects of several thrifty factors could contribute to the pathogenesis of Type II (non-insulin-dependent) diabetes mellitus. We screened the human UCP1 gene (UCP1) for polymorphisms associated with susceptibility to Type II diabetes.

diabetologia

A polymorphism in the 5' untranslated region and a Met 229 ? Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to Type II diabetes mellitus