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Abnormalities of the basement membrane are thought to contribute to the complications of diabetes. The suitability of the cornea for detecting such abnormalities was assessed by determining its light-scattering index, a quantitative measure of tissue reflectivity in the basement membrane zone, with a confocal biomicroscope.

Abnormal light scattering detected by confocal biomicroscopy at the corneal epithelial basement membrane of subjects with Type II diabetes