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In a recently developed rat model, maternal food restriction from day 15 of pregnancy until weaning induced low birth weight and a 70% reduction of beta-cell mass in the offspring at day 21 after birth. Subsequent renutrition from weaning was insufficient to fully restore beta-cell mass in young adult rats. The aim of this study is to investigate the long-term consequences of early malnutrition on beta-cell mass and function.

Effect of ageing on beta-cell mass and function in rats malnourished during the perinatal period