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Chronic hyperglycaemia, as measured by HbA 1c levels, is a major risk factor for atherosclerosis and cardiovascular disease (CVD) in type 1 diabetes. Our aim was to describe the degree to which the effect of HbA 1c on the risk of CVD is mediated by its effect on traditional risk factors over time, and how these mediation pathways change over time.

diabetologia

The relationship of blood glucose with cardiovascular disease is mediated over time by traditional risk factors in type 1 diabetes: the DCCT/EDIC study