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To the Editor: Maturity onset diabetes of the young (MODY) is an autosomal dominantly inherited form of diabetes that has been extensively described in white populations, but diagnosed with lower frequency in other ethnic groups. Mutations in the GCK, HNF1A and HNF4A MODY genes have been reported in a variety of ethnic groups [1–3], but there are few data on prevalence in non-white ethnic groups. MODY was first reported in a UK South Asian (SA) cohort in a systematic survey of childhood diabetes [4]. A 2006 study revealed a lower than expected frequency of referrals for MODY testing in the UK SA population [5]. The frequency and characteristics of MODY in non-white European populations is important for the precise diagnosis of young-onset diabetes.

South Asian individuals with diabetes who are referred for MODY testing in the UK have a lower mutation pick-up rate than white European people