English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

switch protein 2HFD High-fat dietWAT White adipose tissueTriacylglycerols represent the largest energy reservoir of thebody. The primary fat storage organ is white adipose tissue(WAT), which grows in response to excess energy intake,eventually leading to obesity, and shrinks in response tostarvation. In addition to its function as an energy storageorgan, the finely tuned regulation of triacylglycerol synthesisand degradation in WAT is required for control of circulatinglipid levels. Defective WAT function may result indyslipidaemia and fatty acid overload of non-adipose tissues,inducingectopictriacylglycerol deposition,whichisassociat-ed with insulin resistance, inflammation and impaired meta-bolic function of insulin-sensitive tissues [1]. This can occurin obese individuals when the storage capacity of adiposetissue is exceeded and in patients with loss-of-function muta-tions in genes regulating lipid storage, e.g. mutations in thegene encoding lipid droplet protein perilipin 1, which limitstheaccessoflipasestofatstores,leadingtolipodystrophyandsevere insulin resistance [2]. Thus, efficient fatty acid storagein the form of inert triacylglycerol can be considered as aprotective mechanism counteracting dyslipidaemia and meta-bolic disease.In the current issue of Diabetologia, El-Assaad et al [3]describe the phenotype of mice lacking G0s2, the proteinproduct of which (G

The sparing use of fat: G0s2 controls lipolysis and fatty acid oxidation