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To the Editor: Type 1 diabetes, particularly in the presence of microangiopathy, is associated with cognitive dysfunction, mainly observed in domains involving processing speed, suggesting white matter involvement [1]. White matter hyperintensities, a commonly used marker for white matter damage on MRI, however, do not occur more prevalently in type 1 diabetes compared with controls [2]. Therefore, we assessed white matter tract integrity using MRI-diffusion tensor imaging (DTI) and cognitive functions in type 1 diabetic patients with and without microangiopathy and in controls. We hypothesised that type 1 diabetic patients with microangiopathy would show the most pronounced reductions in white matter tract integrity compared with the other groups, and that these differences would be associated with cognitive differences.

Diffusion tensor imaging in type 1 diabetes: decreased white matter integrity relates to cognitive functions