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To the Editor: The editorial, ‘Latent autoimmune diabetes in adults: a guide for the perplexed’ [1] questions the need for the separate classification of autoimmune diabetes developing in adults (latent autoimmune diabetes in adults [LADA]) from the disease developing in childhood (type 1 diabetes). In it Edwin Gale concludes that the evidence is marginal for designation of LADA as a distinct aetiological entity in the burgeoning world of subdivisions of diabetes. We would like to address some of the issues raised with reference to our recent findings in a large cohort of LADA subjects from the UK [2, 3]. We aim to aid the ‘perplexed’ in understanding the complexities of LADA.

Comment on: Gale EAM (2005) Latent autoimmune diabetes in adults: a guide for the perplexed. Diabetologia 48:2195–2199