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Numerous clinical MRI studies have been published that describe an association between the repeated administration of (linear) gadolinium-based contrast agents and increased signal intensity in certain brain areas. In November 2017, the European Commission suspended the use of some of these contrast agents.

Erhöhte Signalintensitäten und Gadolinium-Werte im Gehirn nach Gabe Gadolinium-haltiger MR-Kontrastmittel