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For the evaluation of internal exposure to harmful substances, the Human Biomonitoring Commission of the German Environment Agency (HBM Commission) develops toxicologically justified assessment values (HBM-I and HBM-II values). The HBM-I value corresponds to the concentration of a substance in human biological material below which, according to the current status of assessment, no adverse health effects are to be expected. Consequently, no action is required if the HBM-I value is not exceeded [HBM Commission 1996]. In 2016, the HBM Commission developed HBM-I values of 2 ng PFOA/ml and 5 ng PFOS/ml in blood serum or plasma, respectively. A detailed delineation of supporting arguments was published in April 2018 [HBM Commission 2018]. In contrast to the HBM-I value, the HBM-II value corresponds to the concentration of a substance in human biological material which, when exceeded, may lead to health impairment which is considered as relevant to affected individuals [HBM Commission 1996, 2014].

HBM I values for Perfluorooctanoic acid (PFOA) und Perfluorooctanesulfonic acid (PFOS) in blood plasma