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Isospin-breaking (IB) effects are required for an evaluation of hadronicvacuum polarization at subpercent precision. While the dominant contributionsarise from the $e^+e^-\to\pi^+\pi^-$ channel, also IB in the subleadingchannels can become relevant for a detailed understanding, e.g., of thecomparison to lattice QCD. Here, we provide such an analysis for $e^+e^-\to3\pi$ by extending our dispersive description of the process, includingestimates of final-state radiation (FSR) and $\rho$-$\omega$ mixing. Inparticular, we develop a formalism to capture the leading infrared-enhancedeffects in terms of a correction factor $\eta_{3\pi}$ that generalizes theanalog treatment of virtual and final-state photons in the $2\pi$ case. Theglobal fit to the $e^+e^-\to 3\pi$ data base, subject to constraints fromanalyticity, unitarity, and the chiral anomaly, gives $a_\mu^{3\pi}|_{\leq1.8\,\text{GeV}}=45.91(53)\times 10^{-10}$ for the total $3\pi$ contribution tothe anomalous magnetic moment of the muon, of which$a_\mu^\text{FSR}[3\pi]=0.51(1)\times 10^{-10}$ and$a_\mu^{\rho\text{-}\omega}[3\pi]=-2.68(70)\times 10^{-10}$ can be ascribed toIB. We argue that the resulting cancellation with $\rho$-$\omega$ mixing in$e^+e^-\to 2\pi$ can be understood from a narrow-resonance picture, and provideupdated values for the vacuum-polarization-subtracted vector-meson parameters$M_\omega=782.70(3)\,\text{MeV}$, $M_\phi=1019.21(2)\,\text{MeV}$,$\Gamma_\omega=8.71(3)\,\text{MeV}$, and $\Gamma_\phi=4.27(1)\,\text{MeV}$.

Isospin-breaking effects in the three-pion contribution to hadronic vacuum polarization