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Next-to-leading order (NLO) QCD predictions for the production of heavyquarks in proton-proton collisions are presented within three differentapproaches to quark mass, resummation and fragmentation effects. In particular,new NLO and parton shower simulations with POWHEG are performed in the ALICEkinematic regime at three different centre-of-mass energies, including scaleand parton density variations, in order to establish a reliable baseline forfuture detailed studies of heavy-quark suppression in heavy-ion collisions.Very good agreement of POWHEG is found with FONLL, in particular for centrallyproduced D^0, D^+ and D^*+ mesons and electrons from charm and bottom quarkdecays, but also with the generally somewhat higher GM-VFNS predictions withinthe theoretical uncertainties. The latter are dominated by scale rather thanquark mass variations. Parton density uncertainties for charm and bottom quarkproduction are computed here with POWHEG for the first time and shown to bedominant in the forward regime, e.g. for muons coming from heavy-flavourdecays. The fragmentation into D_s^+ mesons seems to require further tuningwithin the NLO Monte Carlo approach.

NLO Monte Carlo predictions for heavy-quark production at the LHC: pp collisions in ALICE