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In vitro studies have demonstrated that interleukin (IL)-1β decreases insulin and DNA contents in pancreatic islet β cells, causing structural damage, that it is toxic to cultured human islet β cells and that it is able to induce apoptosis in these cells.

An Imidazoline Compound Completely Counteracts Interleukin-1β toxic Effects to Rat Pancreatic Islet β Cells