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The serotonin transporter is one of a family of sodium-dependent monoamine transporters, which includes those for norepinephrine, dopamine, glycine, and GABA. Many antidepressant agents function by inhibiting the serotonin transporter, and the highly effective serotonin selective reuptake inhibitors (SSRIs), such as fluoxetine (Prozac), do so very specifically. In 1996 molecular genetic studies demonstrated an association between allelic variation in the gene for the serotonin transporter and susceptibility to affective disorder (depression and manic depressive illness), and they suggested that this gene may be important in determining the inheritance of certain "normal" personality traits, most notably, those grouped under the heading 'neuroticism." In addition, the molecular biology of regulation of the serotonin transporter gene is beginning to be unravelled.

Association between the serotonin transporter gene and affective disorder: The evidence so far