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The apolipoprotein E (apoE) type ε4 isoform specifies increased cerebral and cerebrovascular accumulation of amyloid-β protein (Aβ) and contributes to the genetic susceptibility underlying a large proportion (~60%) of typical, sporadic Alzheimer disease. Unfortunately, in vitro biochemical studies of direct apoE isoform-specific interactions with Aβ have been inconsistent, perhaps due to the use by different research groups of apoE isoform preparations in different conformational states (purified denatured versus native).

Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E