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The conformation in solution of new modified nucleosides bearing branched-chain sugars used as building blocks for antisense oligonucleotides is investigated by NMR spectroscopy. Within a classical approach to the conformational study of these molecules, a new methodology is adopted, which is capable of exploring all the possibilities, for a given conformational model, that are compatible with the experimental data. The relationship between conformation of the monomers and hybridization properties of the corresponding oligonucleotides is examined.

Conformational analysis by NMR spectroscopy of 2′-deoxy-2′-C-alkylnucleosides: Building blocks of new antisense fragments