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We previously established that a 5 mg x kg(-1) intraoperative dose can reduce the nausea/vomiting associated with tramadol patient-controlled analgesia (PCA). This study was conducted to identify the most appropriate initial dose to improve the quality of tramadol PCA.

Tramadol 2.5 mg·kg−1 appears to be the optimal intraoperative loading dose before patient-controlled analgesia