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sible mechanism involved in decreasing propofol pain by dexmedetomidine might be venous alpha1and alpha2-stimulation resulting in release of vasodilator prostaglandins that antagonize the venoconstrictor response. This modulates the sympathetic response of venous smooth muscle and may be important in endothelial dysfunction caused by propofol.3 In conclusion, dexmedetomidine decreases propofol injection pain as effectively as lidocaine, and can be an alternative to other pretreatment drugs.

canadian journal of anaesthesia/canadian journal of anesthesia

‘Patients who sing need to be relaxed’-neuromuscular blockade as a solution for air-leaking during intermittent positive pressure ventilation using LMA