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The auditory evoked potential (AEP) has been proposed as a method to determine depth of anesthesia, as AEPs are generated in the thalamus and cerebral cortex. Because general anesthesia, in part, relies on anesthetic action in the spinal cord, we hypothesized that isoflurane would have indirect depressant effects on the AEP because of its action in the spinal cord.

Isoflurane indirectly depresses middle latency auditory evoked potentials by action in the spinal cord in the goat