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Summary  Plasma levels of antidiuretic hormone (ADH) increased in seven patients during cardiac surgery using extra-corporeal circulation, probably due to changes in serum osmolalities, surgical trauma and the action of anaesthetic drugs.  The levels of A.D.H. returned to pre-operative levels within a few hours following in all but two of the seven patients. The treatment of these two patients differed only in that they received higher doses of morphine than the other subjects.    The level of A.D.H. remained high following three hours of spontaneous respiration and this would seem to discount the importance of I.P.P.V. as a stimulus to A.D.H. secretion.

Plasma levels of anti-diuretic hormone during and after heart surgery with extra corporeal circulation