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This study examined the effect of high cerebral concentrations of isoflurane on the electroencephalogram (EEG) and motor activity while using an experimental preparation in which isoflurane can be selectively delivered to the in situ goat brain. In a previous study we found that isoflurane (&gt; 6%), when selectively delivered to the brain, was associated with spontaneous movement.

Movement associated with high cerebral concentrations of isoflurane: no evidence of seizure activity