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Summary  Fifteen patients ranging in age from 30 to 64 years and undergoing cardiac surgery were studied preoperatively and after premedication to assess the effects of narcotic-belladonna premedication on changes in physiological dead space (Vdphys), when inspired oxygen was varied from 20.95 per cent to 100 per cent. Measurements of arterial blood gases, end-tidal and mixed expired gases showed that there was a significant increase in dead space/tidal volume ratio VD/VT) when the inspired oxygen concentration was increased. Combined narcotic and belladonna premedication did not significantly affect VD/VT ratios when the same increase in inspired oxygen occurred.  Absolute values of VDPHYS are increased by high tidal volumes and this should be correlated with the VD/VT changes to aid in the clinical interpretation. It is likely that narcotic-belladonna premedication does not contribute to the increase in dead space which is found in the anaesthetized patient.

The dead space after addition of oxygen and premedication with narcotics and belladonna drugs