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Poor and variable spatial resolution of the gamma camera, the movement of the heart and, above all, the inclusion of scattered photons in the acquisition data contribute to the deterioration of image contrast in 201Tl myocardium perfusion studies. Scatter correction algorithms may correct for the latter factor by removing (most of) the scattered photons from the acquisition data.

Scatter correction on its own increases image contrast in TI-201 myocardium perfusion scintigraphy, but does it also improve diagnostic accuracy?