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The early studies on proteinase-catalyzed peptide bond synthesis are summarized as background for a report on some recent work in our laboratory on pepsin and thermolysin. The primary and secondary specificity of these two enzymes have been found to be suitable for the preparative synthesis of oligopeptides by the condensation of two hydrophobicl-amino acid residues. Kinetic data are presented showing that the rate of entry of each of the two components in a thermolysin-catalyzed condensation reaction depends on the nature of the other component, and that this effect is related to differences in the transition-state conformation of the enzyme-reactant complexes.

Pepsin and thermolysin as catalysts of peptide bond synthesis