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This paper brings up many important issues regarding plantderived compounds with estrogenic activity. The authors correctly emphasize the need for control of estrogenicity of foods containing phytoestrogens in view of the significant health effects of various estrogenic derivatives. This is particularly essential in the light of the current wave of enthusiasm for vegetarian food in general and phytoestrogens in particular. The authors give several examples of in vitro assays to test estrogenicity of foodstuff. Some in vivo assays are also described. Needless to say, the latter assays are very important since it is to be expected that many compounds in food do not become estrogenic until after metabolism in the body. Another important aspect that needs to be addressed is whether food derived estrogens primarily act on one or the other of the two ER isoforms. It has been known since several years that certain phytoestrogens preferentially bind to ERβ rather than to ERα (Kuiper et al., 1998) but individual phytoestrogens may show the opposite specificity.

genes and nutrition

Comments to the paper “tools to evaluate estrogenic potency of dietary phytoestrogens: A consensus paper from the EU Thematic Network “Phytohealth” (QLKI-2002-2453)”