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Protective effect of the lipopolysaccharide (LPS) antigen of Klebsiella pneumoniae was tested against ascending-mode urinary tract infection in BALB/c and LACA strains of mice. LPS was given by two different routes; LPS was found to be protective (whatever the application route) since colonization with the challenge organism was significantly lower in both cases as compared with unimmunized mice. A maximum decrease in bacterial count in the kidney of LPS-treated animals was observed on challenge after a 4-d treatment.

Lipopolysaccharide-induced resistance in mice against ascending urinary tract infection withklebsiella pneumoniœ