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Summary The distribution of serum transferrin (Tf), group-specific component (Gc), and red cell phosphoglucomutase-1 (PGM1) subtypes has been studied by polyacrylamide gel and starch-gel electrophoresis followed by isoelectric focusing in a group of 213 Lepchas in the Darjeeling district, West Bengal, India. The frequencies ofTf C1,Tf C2,Tf B andTf DChi were found to be 0.804, 0.182, 0.014 and 0.00 respectively, among the Buddhists and 0.741, 0.244, 0.007 and 0.007, respectively, in the Christian Lepchas. The frequencies of Gc alleles were as follows:Gc 1F 0.587 and 0.539;Gc 1S 0.203 and 0.242;Gc 2 0.210 and 0.215 in these two groups, respectively. The allelic frequencies of PGM1 were found to be 0.706 and 0.714 forPGM 1+; 0.164 and 0.086 forPGM 1−; 0.116 and 0.175 forPGM 2− in Buddhists and Christians, respectively. No rare allele of Tf and PGM1 had been detected but one example of a variant from ofGc 2 allele has been observed among the Christians.

The distribution of transferrin, group-specific component and phosphoglucomutase-1 subtypes among the Lepchas of Darjeeling, Eastern India