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We have previously reported the production in guinea pigs of anti-idiotypic antibodies against (T,G)-A--L-specific antibodies of high responder C3H.SW (H-2 b, Igh-1 a, Herzenberg and Herzenberg 1978), mice (Schwartz et al. 1978). The guinea pig antisera possessed anti-idiotypic antibodies which reacted with bindingsite associated determinants (Schwartz et al. 1978). Immunization with either the closely related antigen (Phe, G)-A--L or with (T,G)-A--L complexed with methylated bovine seicum albumin (MBSA) led to the production of (T,G)-A--L-specific antibodies which possess cross-reactive idiotypes with C3H.SW anti-(T,G)-A--L antibodies (Schwartz et al. 1978, Lifshitz et al. 1978). A limited strain survey suggested a linkage between the expression of idiotypic determinants and the heavy chain constant region Igh-1 a allotypic locus of the mouse (Schwartz et al. 1978). This suggestion was confirmed when (T,G)-A-L specific antibodies of the two congenic strains C3H.SW (H-2 b, Igh-1 a) and CWB (H-2 b, Igh-I b), which differ only in the Igh1 allotypic complex, were tested. We have demonstrated that, whereas the binding of 125 I-C3H.SW anti-(T,G)-A-L antibodies (idiotypes) to guinea pig anti-idiotypic sera was completely inhibited by the homologous antibodies, no inhibition was obtained by excess of CWB anti-(T,G)-A--L antibodies (Schwartz et al. 1978). In the present report we have broadened the number of strains screened for idiotypic expression utilizing (Phe, G)-A--L to which most of the mouse strains respond with the production of (T,G)-A-L-specific antibodies. In addition, genetic analysis was performed in the segregating backcross population between F 1 hybrids of C3H.SW (idiotype +) and CWB (idiotype-) and the CWB parental mice for establishing the suggested linkage between the expression of the inherited idiotypic determinants and the Igh-I ~ allotype.

Linkage of murine (T,G)-A- -L-specific idiotypic determinants to the heavy chain constant region allotypic markers