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Mouse hepatitis virus strain 3 replicated in C57, A/Sn and A/J strain mouse macrophages with the production of a clear cytopathic effect, although only C57 and A/Sn strains of mice were killed with similar MHV3 dilutions. We could not confirm a previous report showing that in vitro cultured macrophages from A/J strain mice were resistant to MHV3 infection.

Mouse hepatitis virus strain 3 infection of C57, A/Sn and A/J strain mice and their macrophages