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Summary Organ cultures of mouse trachea were infected with some indigenous mouse viruses. Mengovirus and reovirus type 3 grew to high titer; inocula of, respectively, 102 and 103 TCID50 were required to initiate infection. Organ cultures supported also the growth of mouse hepatitis viruses, MHV-3 and MHV-S, though to a lesser extent. Viral production was noted for periods of as long as two weeks. None of the viruses had a noticeable effect on the ciliary activity or acquired such capacity on serial passage in organ cultures.

Growth of mouse hepatitis and other indigenous mouse viruses in tracheal organ cultures