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Summary  Intravenous glucose tolerance test, intravenous tolbutamide test, insulin sensitivity and IL A have been investigated in a series of haemochromatosis patients. It appears that decreased carbohydrate tolerance and decreased insulin sensitivity are present in all subjects. — Serum IL A is within or above normal range and increases after tolbutamide administration. On the basis of the data shown, it is suggested that the decreased carbohydrate tolerance occurring in haemochromatosis is due to impaired peripheral glucose utilization, rather than to pancreatic insular insufficiency as postulated by several authors.

Studies on the diabetic syndrome of idiopathic haemochromatosis