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Summary  The relationship of insulin secretion to different types of lipid disorders was studied in 54 nonobese coronary patients with hyperlipidemia. Nineteen patients had hypercholesterolemia and normal triglycerides (type II), and 35 had endogenous hypertriglyceridemia with or without elevated cholesterol levels. Carbohydrate abnormalities and increased insulin concentrations were much more frequent in the hypertriglyceridemic group than in the type II group. Treatment designed to lower insulin levels resulted in no significant serum lipid changes in the type II subjects. In those with hypertriglyceridemia, a decrease in insulin accompanied appreciable falls in triglyceride and cholesterol levels. Mild carbohydrate abnormalities with insulin hypersecretion were closely associated with endogenous hypertriglyceridemia, but appeared to play no major role in type II hyperlipidemia.

The role of endogenous insulin in different hyperlipidemic states