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Sila-AnaloguesB 2 andA 2 of the spasmolytic ciclonium bromide (B 1) respectively the corresponding free baseA 1 were synthesized for the first time according to the reaction steps shown in scheme 1, and they and their precursors I and II were characterized by physical (Table 1) and chemical properties and their structures confirmed by NMR, and mass spectroscopy (Tables 2 and 3). The pharmacological effects ofA 2 andB 2 were investigated and compared with those of the parent carbon compoundB 1 (chapter 5).

Sila-Analogon des Cicloniumbromids