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Bovine chromaffin cells have binding sites for rat atrial natriuretic factor (ANF), as demonstrated autoradiographically by using the 125I-labelled peptide. Patch-clamp recording revealed that ANF reduces acetylcholine (ACh)-induced membrane currents in chromaffin cells at physiological membrane potentials. The effect was dose-dependent with the IC50 value being 5.2 microM ANF and the Hill coefficient close to 1. The channel block was absent at positive membrane potentials, indicating a non-competitive interaction of ANF with the open ACh receptor channel. Fragments of ANF had a much less pronounced action, which is possible due to their structure and molecular charge being different to ANF. The block of nicotinic ACh receptor channels may enable ANF to control the secretion of catecholamines from adrenal chromaffin cells.

Effect of atrial natriuretic factor (ANF) on nicotinic acetylcholine receptor channels in bovine chromaffin cells