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Summary  Nicotinic acid was in acute studies administered to 4 patients with untreated juvenile diabetes and to 4 obese fasting patients. In all cases the plasma level of FFA decreased. This was soon followed by a decrease in plasma -hydroxybutyric acid. The effects were less prompt and pronounced in the obese fasting subjects. There were lesser changes in the concentration of blood glucose.

Plasma ?-hydroxybutyric acid response to nicotinic acid-induced plasma free fatty acid decrease in man