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Summary  A quantitative study of electron micrographs prepared from renal biopsies in 7 young patients with recent diabetes mellitus and from 3 non-diabetics is presented. In all the diabetic patients a biopsy was taken before treatment and after the normalization of the metabolic state. Basement membrane thickness was measured at constant intervals on montages of glomerular cross sections. The actual number of measurements varied between 438 and 1745 for each glomerulus. Frequency distribution curves of basement membrane thickness were similar in diabetics and non-diabetics. No difference was found between the results obtained in the first and the second biopsy in the diabetic patients. It is concluded that there is no thickening of the peripheral glomerular basement membrane in recent juvenile diabetes.

A quantitative estimate of the peripheral glomerular basement membrane in recent juvenile diabetes