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W~ST~A~N (1962) initiMly observed that single doses of reserpine were more potent in lowering brain amine levels when given intramuscularly than when administered intraperitoneally. More recently BgAG~T (1964) has reported comparable differences when cardiac amine levels were also studied following various single doses of reserpine. His data clearly demonstrates that both the intramuscular and the subcutaneous routes were more potent than the intraperitoneal route of administration. It has further been demonstrated in these laboratories that the degree of toxicity from chronic reserpine treatment can also be influenced by route of administration. Methods ttOLTZMA~ (Wisconsin) male albino rats were used in this experiment. Reserpine (kindly supplied by CIBA, Inc., Summit, N.J.) was administered daily either subcutaneously or intraperitoneally in the following vehicle: 5% polyethylene glycol 300, 1% benzyl alcohol and 0.25% citric acid. Control rats received 1 ml/kg of this vehicle. Experimental groups were selected randomly and animals were housed two/cage for convenience in estimating food and water consumption. Food and water intake was measured by difference. Each group received 50 g/day of purina rat chow which was placed directly inside the cage. These animals were also presented 125 ml/day H~O via standard water bottles. Due to the high degree of physical deterioration and difficulty in handling chronic reserpinized animals, certain criteria for the duration of any single experiment were used. Drug administration to any experimental group was terminated when either an LD-50 was attained, or when the mean body weight of the group had decreased by more than 30~ .

Effects of route of administration on the chronic toxicity of reserpine