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The ability to mount immune responses to T-dependent antigens is controlled by four genes that map to the I region of the murine major histocompatibility complex (McDevitt et al. 1981, Nagy et al. 1981). These Ir genes code for four distinct Ia polypeptide chains, As, Ap, E~, and E,, which associate to form the I-A (As; Ap) and I-E (E~;Ep) molecules (Uhr et al. 1979, Vitetta and Capra 1979). Restriction endonuclease analysis of the I region in H-2 recombinants with intra-I-region crossover events has demonstrated that tfiese recombinatorial events are concentrated in the area between the Ep and E= genes (Steinmetz et al. 1982, Hood et al. 1983). There are three previously described exceptions to this rule. D2.GD (H-2 °2) and A.TFR5 (H-2 apS) have intragenic recombinatorial events within the E~ gene (Jones 1981, Lafuse et al. 1980), while B10.STA62 has a recombinatorial event that separates the A~Ap duplex from the Ep gene (Singh et al. 1981). In this report, we describe two new H-2 haplotypes that very likely arose by recombination between the Ep locus and the A~A~ segment and one haplotype that may have arisen by recombination between the E~ and E~ loci. The current assignments of the I region alleles for B10.ASR7 (H-2as3), B10.BAR4 (H-2h6), and B10.BASR1 (//-2 a~4) were based on cytotoxicity data and indicated that in all three recombinant strains the crossover event occurred between the genes for H-2K and E~ (Klein et al. 1983). These three strains were then examined for expression of defined Ia specificities to determine whether the recombinant strain I-A molecule more closely resembled one parent or the other (Table 1). As determined by microcytotoxicity and confirmed by immunofluorescence (data not shown), the I-A molecules of all three strains exhibited monoclonal antibody binding patterns consistent with the k haplotype, in that 11.4.1 (H-2K k, m93), 11.5.2 (I-A k, m2), 10.2.16 (I-A k, I-A s, I-A f, m27), and 17/227 (I-A k, I-A b, I-A d, m15) bound, but MK-S4 (I-A s) and 28-16-8S (I-A b, I-A d, m8) failed to bind. Competitive inhibition radioimmunoassays performed to evaluate whether the

Characterization of three new intra-I region recombinant mouse strains, B10.ASR7 (H-2 as3 ), B10.BAR4 (H-2 h6 ), and B10.BASR1 (H-2 as4 )