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B. S. Baker, L Fry, and A. V. Powles Department of Dermatology, St. Mary's Hospital, London W2, UK 9 Springer-Verlag 1990 Key words: Sandimmun - Psoriasis - T lymphocytes - Dendritic cells Editor, We would like to point out an error made by Gupta et al. [Archives of Dermatological Research (1989) 281:219- 226] when describing a similar study carried out by us [Baker et al., British Journal of Dermatology (1987) 116: 503] to investigate the effects of Sandimmun on T lymphocyte and dendritic cell subpopulations in pso- riasis. It was stated that we had looked at changes in immune cell types in psoriatic lesions treated with Sandimmun at time intervals ranging between 10 and 90 days after Sandimmun therapy. In fact, we had studied biopsies at 3 and 7 days (which is at the same time that Gupta et al. took their early biopsies) before clinical treatment was apparent, in addition to those taken at 2, 3, 4, 6, 8, and 12 weeks of treatment. Thus, the study by Gupta et al. differed very little from the one carried out by us 2 years previously, apart from the use of much higher doses of Sandimmun - 14 compared to 3 mg/kg per day in our study. It should be stressed that a dose of 14 mg/kg per day is unnecessarily high to clear' psoriasis and will produce a greater incidence of serious side-ef- fects. A dose of 3 mg/kg per day is usually sufficient to improve psoriasis and, it is of interest to note, produces an effect on T lymphocytes and dendritic cells that is similar to the higher dose.

Effects of Sandimmun on T lymphocyte and dendritic cell subpopulations in psoriasis