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Variant Hepatic Nuclear Factor l (vHNF1), also called TCF2, HNFI[3, or LFB3, is a nuclear protein that binds to proximal promoter sequences of a and [3 fibrinogen and albumin. The protein was first identified in dedifferentiated rat hepatoma cell lines (Baumhueter et al. 1988; Cereghini et al. 1988). The mRNA is found in significant levels in adult rat and mouse kidney and in low levels in liver, intestine, and lung (ReyCampos et al. 1991; De Simone et al. 1991; Mendel et al. 1991). The cDNA corresponding to the rat mRNA has been isolated and sequenced from the dedifferentiated hepatoma H5 cell line (Rey-Campos et al. 1991). The human and mouse cDNAs have also been isolated and share approximately 93% sequence homology with the rat cDNA (Bach et al. 1991; De Simone et al. 1991; Mendel et al. 1991). The gene codes for a homeoprotein homologous to Hepatic Nuclear Factor l (HNF1) or LFBI in regions important for DNA binding and dimerization while the sequence is highly divergent in the transactivation domain. Both HNF1 and vHNF1 act as transcriptional activators of the albumin promoter in transient co-transfection experiments, and these proteins form heterodimers (Rey-Campos et al. 1991). Though HNFI and vHNF1 are two closely related homeoproteins, they are localized on different chromosomes. HNF1 has been previously mapped to mouse Chr 12 and human Chr 5 (Bach et al. 1990). Transcription factor 2 (Tcf-2) has been assigned to mouse Chr 11 and human Chr 17 by analysis of somatic cell hybrids (Milatovich et al. 1991). In situ hybridization has localized the gene to human Chr 17qll.2-q21.1 and mouse Chr llB4-D (Bach et al. 1991). We report chromosomal location of mouse Tcf-2 relative to other previously mapped Chr 11 loci using an intersubspecific mouse backcross. This (DF/ B-df/df x CASA/Rk)F 1 x DF/B-df/df backcross has been typed for 12 loci on Chr 11 (Buckwalter et al.

The gene coding for variant hepatic nuclear factor 1 (Tcf-2), maps between the Edp-1 and Erba genes on mouse Chromosome 11