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Sir, Boelsterli and Zbinden (1985) reported in this journal on biochemical and morphological changes of the rat adrenal medulla induced by xylitol. This paper was interesting, multifaceted and it elucidated an important biomedical is- sue related to xylitol which is becoming a leading nutritive sucrose substitute by virtue of its noncariogenicity and an- ticariogenicity, and its suitability in the diabetic diet. Al- though the methodology and the presentation of data of the above paper were by and large impeccable, we oppose the authors' view, presented in their Discussion, that per- oral administration of xylitol would cause hyperinsulinem- ia and hypoglycemia. Our perusal of the study of Boelsterli and Zbinden showed that some of the data presented does not justify the conclusions made. Our view is based on the following methodological features and conclusions of their study.

Biochemical and morphological changes of the rat adrenal medulla induced by peroral xylitol