English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The presence of a polymorphic [CA], dinucleotide microsatellite repeat (Weber and May 1989) in the 3' untranslated region of the human dystrophin gene (Duchenne muscular dystrophy locus, DMD) has been reported (Oudet et al. 1990; Beggs and Kunkel 1990). Sequence analysis of the murine dystrophin cDNA reveals that this dinucleotide repeat is conserved between species and is present at the same location in the mouse and human genes. We have found that the murine dinucleotide repeat, designated UM11, is variable in length among separate mouse species and therefore represents a valuable marker for mapping the X Chromosome (Chr) in interspecific crosses (for example, Chamberlain et al. 1987). The published repeat in the 3' untranslated region of the human dystrophin cDNA has the sequence [CA]7TA[CA] 8 (Koenig et al. 1988). The corresponding dinucleotide repeat in DNA from C57BL/10 mice is [CA]I 7 followed closely by a second [CA]13. Recently Moore et al. (1991) searched Genbank 66.0 and found 32 dinucleotide repeats conserved among different species of mammals. Only one of these sequences occurred in a coding region; the others were in introns or intergenic regions. It is unusual to have [CA]n repeats in mRNAs, and the conservation of the dystrophin 3' [CA]n repeat through evolutionary time is striking. It has previously been noted that the highest degree of sequence identity between the human and the chicken dystrophin cDNA sequences occurs not in the coding sequences but in the 5' end of the 3' untranslated region (LeMaire et al. 1988). This is also true when the murine sequence (Chamberlain et al.: GenBank accession #M68859) is included in the comparison. We

Cross-species conservation of a polymorphic dinucleotide repeat in the dystrophin gene