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With the development of photoscanning clinical medicine now possesses a diagnostic technique in which further advances will depend heavily upon pharmacologic investigations of structure-distribution relations. In the present study the distribution of the selenium analogs of thiouracil and thiourea, labeled with Selenium-75, was studied in rabbits. After administration of either compound, high concentrations of Se 75 were found in the lung, liver and kidney. The concentration of Se 75 in the lungs after administration of these compounds, especially Se 75 -selenouracil, permitted visualization of the lungs in the living, intact animal by photoscanning. However, neither Se 75 -selenouracil nor Se 75 -selenourea permit pulmonary scans of high quality and these particular compounds are not recommended for trial in man. The possible relation of labelled compounds of this type, as well as certain other series of labeled compounds, to the problem of adrenal scanning is also discussed

The tissue distribution of Se75-selenouracil and Se75-selenourea