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Orofacial region and dental tissues harbour a wide range of stem/progenitor cells including mesenchymal stem cells and tissue-specific progenitors such as muscle satellite cells. The stem cells of the orofacial areas are readily available, highly proliferative and possess multi-differentiation abilities. These cells not only provide therapeutic and tissue engineering cell source for the defects of orofacial area and dental tissues but also provide additional cell source for the diseases of other organs. Understanding their differentiation pathways and mechanisms will be imperative in developing the most appropriate approaches for stem cell-based tissue engineering and therapeutic strategies.

Orofacial Stem Cells for Cell-Based Therapies of Local and Systemic Diseases