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The mammals and birds have four chambered hearts. The current models show the majority of myocardial cells derive from the first and second heart field, however, little is known regarding how heart field subpopulations contribute to specific regions in the heart. In this study, we revealed that the early Ednra-positive population in the inflow tract region contributes to the chamber myocardium by mouse-chick chimera and CreERT2/loxP lineage tracing system.

Endothelin Receptor Type A-Expressing Cell Population in the Inflow Tract Contributes to Chamber Formation