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Characterization and quantification of diffuse parenchymal lung disease (DPLD) severity using MDCT, mainly in interstitial lung diseases and emphysema, is an important issue in clinical research for the evaluation of new therapies. This paper develops a 3D automated approach for detection and diagnosis of DPLDs (emphysema, fibrosis, honeycombing, ground glass). The proposed methodology combines multi-resolution image decomposition based on 3D morphological filtering, and graph-based classification for a full characterization of the parenchymal tissue. The very promising results obtained on a small patient database are good premises for a near implementation and validation of the proposed approach in clinical routine.

Diffuse Parenchymal Lung Diseases: 3D Automated Detection in MDCT